Serveur d'exploration MERS

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Atypical presentations of MERS-CoV infection in immunocompromised hosts

Identifieur interne : 000E83 ( Main/Exploration ); précédent : 000E82; suivant : 000E84

Atypical presentations of MERS-CoV infection in immunocompromised hosts

Auteurs : Si-Ho Kim [Corée du Sud] ; Jae-Hoon Ko [Corée du Sud] ; Ga Eun Park [Corée du Sud] ; Sun Young Cho [Corée du Sud] ; Young Eun Ha [Corée du Sud] ; Ji-Man Kang [Corée du Sud] ; Yae-Jean Kim [Corée du Sud] ; Hee Jae Huh [Corée du Sud] ; Chang-Seok Ki [Corée du Sud] ; Byeong-Ho Jeong [Corée du Sud] ; Jinkyeong Park [Corée du Sud] ; Jun Ho Jang [Corée du Sud] ; Won Seog Kim [Corée du Sud] ; Cheol-In Kang [Corée du Sud] ; Doo Ryeon Chung [Corée du Sud] ; Jae-Hoon Song [Corée du Sud] ; Kyong Ran Peck [Corée du Sud]

Source :

RBID : PMC:7129274

Descripteurs français

English descriptors

Abstract

During the 2015 Korean MERS outbreak, we experienced atypical presentations of MERS-CoV infections in three immunocompromised hosts that warranted exceptional management. Case 1 showed delayed symptom development after a four-day asymptomatic period, Case 2 experienced a 20-day incubation period, and Case 3 exhibited persistent viral shedding without clinical deterioration. Recognizing these exceptions is extremely important in the management of MERS-CoV-exposed or -infected patients and for control of potential MERS outbreaks.


Url:
DOI: 10.1016/j.jiac.2017.04.004
PubMed: 28545936
PubMed Central: 7129274


Affiliations:


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Le document en format XML

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<name sortKey="Jang, Jun Ho" sort="Jang, Jun Ho" uniqKey="Jang J" first="Jun Ho" last="Jang">Jun Ho Jang</name>
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<nlm:aff id="aff6">Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul</wicri:regionArea>
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<settlement type="city">Séoul</settlement>
<region type="capital">Région capitale de Séoul</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Kim, Won Seog" sort="Kim, Won Seog" uniqKey="Kim W" first="Won Seog" last="Kim">Won Seog Kim</name>
<affiliation wicri:level="3">
<nlm:aff id="aff6">Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul</wicri:regionArea>
<placeName>
<settlement type="city">Séoul</settlement>
<region type="capital">Région capitale de Séoul</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Kang, Cheol In" sort="Kang, Cheol In" uniqKey="Kang C" first="Cheol-In" last="Kang">Cheol-In Kang</name>
<affiliation wicri:level="1">
<nlm:aff id="aff1">Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 135-710, Republic of Korea</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 135-710</wicri:regionArea>
<placeName>
<settlement type="city">Séoul</settlement>
<region type="capital">Région capitale de Séoul</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Chung, Doo Ryeon" sort="Chung, Doo Ryeon" uniqKey="Chung D" first="Doo Ryeon" last="Chung">Doo Ryeon Chung</name>
<affiliation wicri:level="1">
<nlm:aff id="aff1">Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 135-710, Republic of Korea</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 135-710</wicri:regionArea>
<placeName>
<settlement type="city">Séoul</settlement>
<region type="capital">Région capitale de Séoul</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Song, Jae Hoon" sort="Song, Jae Hoon" uniqKey="Song J" first="Jae-Hoon" last="Song">Jae-Hoon Song</name>
<affiliation wicri:level="1">
<nlm:aff id="aff1">Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 135-710, Republic of Korea</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 135-710</wicri:regionArea>
<placeName>
<settlement type="city">Séoul</settlement>
<region type="capital">Région capitale de Séoul</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Peck, Kyong Ran" sort="Peck, Kyong Ran" uniqKey="Peck K" first="Kyong Ran" last="Peck">Kyong Ran Peck</name>
<affiliation wicri:level="1">
<nlm:aff id="aff1">Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 135-710, Republic of Korea</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 135-710</wicri:regionArea>
<placeName>
<settlement type="city">Séoul</settlement>
<region type="capital">Région capitale de Séoul</region>
</placeName>
</affiliation>
</author>
</analytic>
<series>
<title level="j">Journal of Infection and Chemotherapy</title>
<idno type="ISSN">1341-321X</idno>
<idno type="eISSN">1437-7780</idno>
<imprint>
<date when="2017">2017</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc>
<textClass>
<keywords scheme="KwdEn" xml:lang="en">
<term>Adult</term>
<term>Antiviral Agents (therapeutic use)</term>
<term>Blood Component Transfusion</term>
<term>Coronavirus Infections (diagnosis)</term>
<term>Coronavirus Infections (epidemiology)</term>
<term>Coronavirus Infections (therapy)</term>
<term>Coronavirus Infections (virology)</term>
<term>Disease Outbreaks (prevention & control)</term>
<term>Fatal Outcome</term>
<term>Female</term>
<term>Glucocorticoids (therapeutic use)</term>
<term>Hematologic Neoplasms (therapy)</term>
<term>Humans</term>
<term>Immunocompromised Host</term>
<term>Immunosuppression (adverse effects)</term>
<term>Infectious Disease Incubation Period</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Middle East Respiratory Syndrome Coronavirus (isolation & purification)</term>
<term>Middle East Respiratory Syndrome Coronavirus (physiology)</term>
<term>Peripheral Blood Stem Cell Transplantation (adverse effects)</term>
<term>Republic of Korea (epidemiology)</term>
<term>Reverse Transcriptase Polymerase Chain Reaction</term>
<term>Time Factors</term>
<term>Tomography, X-Ray Computed</term>
<term>Virus Shedding</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr">
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Antiviraux (usage thérapeutique)</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient (isolement et purification)</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient (physiologie)</term>
<term>Excrétion virale</term>
<term>Facteurs temps</term>
<term>Femelle</term>
<term>Flambées de maladies ()</term>
<term>Glucocorticoïdes (usage thérapeutique)</term>
<term>Humains</term>
<term>Immunosuppression thérapeutique (effets indésirables)</term>
<term>Infections à coronavirus ()</term>
<term>Infections à coronavirus (diagnostic)</term>
<term>Infections à coronavirus (virologie)</term>
<term>Infections à coronavirus (épidémiologie)</term>
<term>Issue fatale</term>
<term>Mâle</term>
<term>Période d'incubation de maladie infectieuse</term>
<term>RT-PCR</term>
<term>République de Corée (épidémiologie)</term>
<term>Sujet immunodéprimé</term>
<term>Tomodensitométrie</term>
<term>Transfusion de composants du sang</term>
<term>Transplantation de cellules souches de sang périphérique (effets indésirables)</term>
<term>Tumeurs hématologiques ()</term>
</keywords>
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<term>Antiviral Agents</term>
<term>Glucocorticoids</term>
</keywords>
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<term>Immunosuppression</term>
<term>Peripheral Blood Stem Cell Transplantation</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en">
<term>Coronavirus Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr">
<term>Infections à coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr">
<term>Immunosuppression thérapeutique</term>
<term>Transplantation de cellules souches de sang périphérique</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en">
<term>Coronavirus Infections</term>
<term>Republic of Korea</term>
</keywords>
<keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en">
<term>Middle East Respiratory Syndrome Coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr">
<term>Coronavirus du syndrome respiratoire du Moyen-Orient</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr">
<term>Coronavirus du syndrome respiratoire du Moyen-Orient</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en">
<term>Middle East Respiratory Syndrome Coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en">
<term>Disease Outbreaks</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en">
<term>Coronavirus Infections</term>
<term>Hematologic Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr">
<term>Antiviraux</term>
<term>Glucocorticoïdes</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr">
<term>Infections à coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en">
<term>Coronavirus Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr">
<term>Infections à coronavirus</term>
<term>République de Corée</term>
</keywords>
<keywords scheme="MESH" xml:lang="en">
<term>Adult</term>
<term>Blood Component Transfusion</term>
<term>Fatal Outcome</term>
<term>Female</term>
<term>Humans</term>
<term>Immunocompromised Host</term>
<term>Infectious Disease Incubation Period</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Reverse Transcriptase Polymerase Chain Reaction</term>
<term>Time Factors</term>
<term>Tomography, X-Ray Computed</term>
<term>Virus Shedding</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr">
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Excrétion virale</term>
<term>Facteurs temps</term>
<term>Femelle</term>
<term>Flambées de maladies</term>
<term>Humains</term>
<term>Infections à coronavirus</term>
<term>Issue fatale</term>
<term>Mâle</term>
<term>Période d'incubation de maladie infectieuse</term>
<term>RT-PCR</term>
<term>Sujet immunodéprimé</term>
<term>Tomodensitométrie</term>
<term>Transfusion de composants du sang</term>
<term>Tumeurs hématologiques</term>
</keywords>
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<front>
<div type="abstract" xml:lang="en">
<p>During the 2015 Korean MERS outbreak, we experienced atypical presentations of MERS-CoV infections in three immunocompromised hosts that warranted exceptional management. Case 1 showed delayed symptom development after a four-day asymptomatic period, Case 2 experienced a 20-day incubation period, and Case 3 exhibited persistent viral shedding without clinical deterioration. Recognizing these exceptions is extremely important in the management of MERS-CoV-exposed or -infected patients and for control of potential MERS outbreaks.</p>
</div>
</front>
<back>
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</back>
</TEI>
<affiliations>
<list>
<country>
<li>Corée du Sud</li>
</country>
<region>
<li>Région capitale de Séoul</li>
</region>
<settlement>
<li>Séoul</li>
</settlement>
</list>
<tree>
<country name="Corée du Sud">
<region name="Région capitale de Séoul">
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</country>
</tree>
</affiliations>
</record>

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